I think the B16 could work, it's certainly an interesting proposal. My only problem is that it's basically the B60 and B42 into one route with an extension to Queens, and I'm not sure if there's such a high demand for people wanting to go from Canarsie to Atlas Mall, especially when Gateway Center is probably a lot closer for people in Brooklyn.
As for the B22, I don't see it working too well, since it's basically just a combination of the B25 (which runs 1-2 blocks away from your proposed routing) and the Q24 (which follows most of the eastern portion of your route). Not to mention that traffic along Atlantic Avenue can be terrible at times. Plus, there's the problem with the actual demand for the route. If a lot of people transfer from the Q24 to the B25 or vice versa, then I'd say that this route could probably work but that's not the case. You also have the and the running parallel to both the B25 and Q24 respectively, and to your proposed route as well, so if people did want the commute from Pier 6 to Jamaica, I'm sure most people would rather just take the train.